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Esta enzima es relevante en la ruta del mevalonato, una ruta metabólica importante, presente en todos los eucariotas superiores y muchas bacterias, que se esquematiza en el siguiente diagrama.
El enzima está presente en dos formas en el organismo humano, denominadas respectivamente ACAT1 y ACAT2. ACAT1 está codificada por un gen localizado en el cromosoma 11. ACAT2 está codificada por un gen localizado en el cromosoma 6.
Referencias
↑Heath RJ, Rock CO (octubre de 2002). «The Claisen condensation in biology». Nat Prod Rep19 (5): 581-96. PMID12430724.
↑Haapalainen AM, Meriläinen G, Wierenga RK (enero de 2006). «The thiolase superfamily: condensing enzymes with diverse reaction specificities». Trends Biochem. Sci.31 (1): 64-71. PMID16356722. doi:10.1016/j.tibs.2005.11.011.
Datos: Q24782380
Esta página se editó por última vez el 27 dic 2019 a las 00:05.